Selectivity—Key to Chemotherapy: Presidential Address1

نویسنده

  • Gertrude B. Elion
چکیده

For many years, chemotherapists have sought the touchstone which would turn lead into gold, the magic bullet of Ehrlich which would go directly to the target without harming normal cells. There have been many approaches to this goal, but in essence there have been two main philosophies. One is that you should find the basic biochemical differences between the target and the host, whether the target is a bacterium, a virus, a protozoan, or a cancer cell, and then seek ways to utilize this information. The other approach has been more impatient. It is the one which George H. Hitchings has called "Enlightened Empiricism." It says

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تاریخ انتشار 2006